Delirium is a common problem in the ICU that is often undiagnosed if not screened for with a validated tool. It is an independent predictor of outcomes that matter, including increased health care costs, duration of ICU and hospital stay, mortality, and long-term cognitive impairment. Evidence supports the best approach to reducing the burden of this problem for our patients is not a specific drug, but rather embracing a nonpharmacological bundle of safety steps summarized in the ABCDEF (A2F) bundle. The A2F focuses on managing delirium causes, reducing sedation/ventilation/immobility, incorporating family, and rehumanizing critical care.