Table 3.
Multivariate Cox proportional hazards model on overall survival using raw VISTA scores in MPM (n = 317)
| Hazard ratio | 95% CI of HR | p-value | Concordance index | |
|---|---|---|---|---|
| VISTA raw score (10 percent increment) | 0.94 | 0.91 to 0.98 | 0.001 | 0.661 |
| Histology | ||||
| Biphasic vs. epithelioid | 1.5 | 1.1 to 2.2 | 0.020 | |
| Sarcomatoid vs. epithelioid | 1.8 | 1.1 to 2.9 | 0.011 | |
| Stage | ||||
| 2 vs. 1 | 1.8 | 0.92 to 3.6 | 0.084 | |
| 3 vs. 1 | 3.0 | 1.5 to 5.9 | 0.001 | |
| 4 vs. 1 | 3.6 | 1.8 to 7.4 | <0.001 | |
| Age | 1.0 | 1.0 to 1.0 | 0.406 | |
| Gender, male vs. female | 1.6 | 1.2 to 2.1 | <0.001 |
CI confidence interval, HR hazard ratio, MPM malignant pleural mesothelioma, n number, vs. versus, VISTA V-domain Ig suppressor of T-cell activation