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. Author manuscript; available in PMC: 2021 Aug 16.
Published in final edited form as: Mod Pathol. 2019 Sep 19;33(2):303–311. doi: 10.1038/s41379-019-0364-z

Table 3.

Multivariate Cox proportional hazards model on overall survival using raw VISTA scores in MPM (n = 317)

Hazard ratio 95% CI of HR p-value Concordance index
VISTA raw score (10 percent increment) 0.94 0.91 to 0.98   0.001 0.661
Histology
 Biphasic vs. epithelioid 1.5 1.1 to 2.2   0.020
 Sarcomatoid vs. epithelioid 1.8 1.1 to 2.9   0.011
Stage
 2 vs. 1 1.8 0.92 to 3.6   0.084
 3 vs. 1 3.0 1.5 to 5.9   0.001
 4 vs. 1 3.6 1.8 to 7.4 <0.001
Age 1.0 1.0 to 1.0   0.406
Gender, male vs. female 1.6 1.2 to 2.1 <0.001

CI confidence interval, HR hazard ratio, MPM malignant pleural mesothelioma, n number, vs. versus, VISTA V-domain Ig suppressor of T-cell activation