Table 4.
Multivariate Cox proportional hazards model on overall survival using raw PD-L1 scores in MPM (n = 302)
| Hazard ratio | 95% CI of HR | p-value | Concordance index | |
|---|---|---|---|---|
| PD-L1 raw score (10% increment) | 1.1 | 1.0 to 1.1 | 0.002 | 0.654 |
| Histology | ||||
| Biphasic vs. epithelioid | 1.8 | 1.2 to 2.5 | 0.002 | |
| Sarcomatoid vs. epithelioid | 1.9 | 1.2 to 3.0 | 0.007 | |
| Stage | ||||
| 2 vs. 1 | 2.1 | 1.1 to 4.2 | 0.035 | |
| 3 vs. 1 | 3.2 | 1.6 to 6.3 | <0.001 | |
| 4 vs. 1 | 3.6 | 1.7 to 7.3 | <0.001 | |
| Age | 1.0 | 1.0 to 1.0 | 0.415 | |
| Gender, male vs. female | 1.5 | 1.2 to 2.0 | 0.002 |
CI confidence interval, HR hazard ratio, MPM malignant pleural mesothelioma, n number, PD-L1 programmed cell death-ligand 1, vs. versus