Table 3.
Biomarkers-Guided Strategy and Interventions
PrevAKI trial (Meersch et al90)
|
BigpAK study (Göcze et al131)
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AKRT study (Engelman et al132) [TIMP-2]•[IGFBP7] <0.3 (“fast track recovery”)
|
[TIMP-2]•[IGFBP7] ≥0.3 and ≤2.0
|
[TIMP-2]•[IGFBP7] >2.0
|
Abbreviations: ACEi, angiotensin-converting enzyme inhibitors; AKRT, acute kidney response team; ARBs, angiotensin receptor blockers; BigpAK, Biomarker Guided Intervention for Prevention of Acute Kidney Injury; Hb, hemoglobin; IGFBP7, insulin-like growth factor–binding protein 7; NSAIDs, nonsteroidal anti-inflammatory drugs; PICCO, Pulse index Contour Cardiac Output; PrevAKI, Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers; sCr, serum creatinine; TIMP-2, tissue inhibitor of metalloproteinases-2; UO, urinary output.