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. 2021 Aug 2;9:669132. doi: 10.3389/fcell.2021.669132

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Copyright © 2021 Zhang, Li, Zhong, Zhang, Sun and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MCM5 interacted with HDAC1 and was correlated with poor survival in lung cancer. (A) Silver staining identifies the interacting proteins of MCM5. (B) Molecular docking between MCM5 (PDBID: 6XTX) and HDAC1 (PDBID: 4BKX). (C) Co-immunoprecipitation was used to detect the interaction between MCM5 and HDAC1 in A549 cells. (D) In vitro interaction analysis of truncated MCM5 and HDAC1. (E) HDAC1 expression level in lung cancer tumors and normal liver tissues based on the TCGA dataset. (F) Survival analysis of TCGA samples for the relationship of survival time with MCM5 and HDAC1 expression levels in patients with lung cancer. Data are presented as mean ± SD. *P < 0.05.