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. 2021 Aug 2;9:669132. doi: 10.3389/fcell.2021.669132

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Copyright © 2021 Zhang, Li, Zhong, Zhang, Sun and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MCM5/HDAC1 complex promoted lung cancer migration and invasion. After MCM5 and HDAC1 were expressed separately or co-expressed in H1975 cells, the cell function and the expression changes of EMT-related markers were detected. (A) Western blot analysis of HDAC1 and MCM5 expression. (B,C) The invasion and migration of H1975 cells after HDAC1 and MCMM5 expression. (D) Morphological changes in MCM5/HDAC1 overexpression H1975 cells after transfection with siMCM5 or siHDAC1 as observed by SEM. (E,F) Results of the invasion and migration of H1975 cells under different treatments. (G) Western blots of H1975 cells of E-cadherin, anti-Vimentin, anti-MMP2, and anti-MMP9 under different treatments. *P < 0.05.