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. 2021 Aug 2;9:669132. doi: 10.3389/fcell.2021.669132

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Copyright © 2021 Zhang, Li, Zhong, Zhang, Sun and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MCM5/HDAC1 complex promoted tumor proliferation and lung cancer metastasis. After H1975 cells overexpressing MCM5 and HDAC1 were inoculated into nude mice, the harvested tumors were used to detect the expression of MCM5, HDAC1, and E-cadherin by IHC test in solid tumors. (A) Images of tumors under different treatments. (B) Evaluation of tumor growth at different times. (C,D) Detection of MCM5, HDAC1, and E-cadherin expressions in tumors through immunohistochemistry. (E) Representative images of in vivo bioluminescence imaging. *P < 0.05.