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Approach to desensitization. a) All candidates (n=4) were treated with multiple cycles of PI therapy and belatacept. Plasmapheresis was added in cases 3 (cycle 2, 3) and 4. (b) Detailed protocol for a representative case (case 3). Bela, belatacept; Bort, bortezomib; Carfilz, carfilzomib; Dex, dexamethasone; IVIG, intravenous immunoglobulin; Pheresis, plasmapheresis; Txp, transplant.
*Case 4 not transplanted
