Table 3.
Multivariable adjusted associations of baseline body composition measures with risk of HF events
| Model 1 | Model 2 | Model 3 | ||||||
|---|---|---|---|---|---|---|---|---|
| Person- years | Event rate per 1,000 person years |
HR (95% CI) |
P value | HR (95% CI) |
P value | HR (95% CI) |
P value | |
| Per 10 kg higher predicted fat mass | ||||||||
| Overall HF | 58,018 | 4.43 | 1.29 (1.14, 1.46) |
<0.001 | 0.98 (0.86, 1.13) |
0.83 | 0.94 (0.76, 1.16) |
0.56 |
| HFpEF | 57,956 | 2.23 | 1.35 (1.14, 1.60) |
<0.001 | 1.02 (0.84, 1.24) |
0.83 | 0.98 (0.73, 1.31) |
0.88 |
| HFrEF | 57,956 | 1.79 | 1.15 (0.94, 1.40) |
0.19 | 0.94 (0.75, 1.18) |
0.60 | 0.85 (0.60, 1.21) |
0.37 |
| Per 10 kg higher predicted lean mass | ||||||||
| Overall HF | 58,018 | 4.43 | 1.32 (1.15, 1.52) |
<0.001 | 1.05 (0.90, 1.22) |
0.53 | 1.12 (0.90, 1.40) |
0.33 |
| HFpEF | 57,956 | 2.23 | 1.35 (1.11, 1.64) |
0.003 | 1.05 (0.86, 1.30) |
0.63 | 1.08 (0.79, 1.47) |
0.64 |
| HFrEF | 57,956 | 1.79 | 1.25 (1.00, 1.57) |
0.05 | 1.08 (0.85, 1.37) |
0.54 | 1.26 (0.89, 1.80) |
0.20 |
| Per 10 cm higher waist circumference | ||||||||
| Overall HF | 58,018 | 4.43 | 1.26 (1.16, 1.38) |
<0.001 | 1.08 (0.97, 1.19) |
0.16 | 1.10 (0.98, 1.22) |
0.10 |
| HFpEF | 57,956 | 2.23 | 1.27 (1.13, 1.43) |
<0.001 | 1.08 (0.94, 1.24) |
0.30 | 1.08 (0.93, 1.26) |
0.31 |
| HFrEF | 57,956 | 1.79 | 1.20 (1.05, 1.38) |
0.01 | 1.08 (0.92, 1.27) |
0.34 | 1.12 (0.95, 1.34) |
0.19 |
Multivariable adjusted Cox proportional hazard models were constructed for each continuous measure of body composition and for each HF outcome with sequential adjustment for potential confounders
Model 1 included age, sex, race/ethnicity, education, income, treatment group
Model 2 included Model 1 covariates plus baseline CRF
Model 3 included Model 2 covariates plus history of hypertension, systolic BP, smoking status, alcohol use status, estimated GFR, diabetes duration, insulin use, HbA1c, history of CVD, predicted fat mass (except for WC model), predicted lean mass (except for WC model)
Abbreviations: BP = blood pressure; CI = confidence interval; CRF = cardiorespiratory fitness; GFR = glomerular filtration rate; HF = heart failure; HFpEF = heart failure with preserved ejection fraction; HFrEF = heart failure with reduced ejection fraction; HR = hazard ratio; WC = waist circumference