Table 4.
Multivariable adjusted associations of changes in body composition measures from baseline to 1-year follow-up with risk of HF events
| Model 1 | Model 2 | |||||
|---|---|---|---|---|---|---|
| Person- years |
Event rate per 1,000 person years |
HR (95% CI) |
P value | HR (95% CI) |
P value | |
| Per 10% decrease in predicted fat mass from baseline to 1-year follow-up | ||||||
| Overall HF | 55,847 | 4.19 | 0.74 (0.64, 0.86) |
<0.001 | 0.80 (0.68, 0.95) |
0.01 |
| HFpEF | 55,715 | 2.08 | 0.72 (0.58, 0.89) |
0.002 | 0.78 (0.61, 0.996) |
0.046 |
| HFrEF | 55,715 | 1.72 | 0.72 (0.57, 0.90) |
0.004 | 0.76 (0.59, 0.97) |
0.03 |
| Per 10% decrease in predicted lean mass from baseline to 1-year follow-up | ||||||
| Overall HF | 55,847 | 4.19 | 0.64 (0.50, 0.81) |
<0.001 | 0.75 (0.55, 1.02) |
0.06 |
| HFpEF | 55,715 | 2.08 | 0.57 (0.40, 0.81) |
0.002 | 0.68 (0.44, 1.06) |
0.09 |
| HFrEF | 55,715 | 1.72 | 0.72 (0.49, 1.04) |
0.08 | 0.88 (0.54, 1.42) |
0.60 |
| Per 10% decrease in waist circumference from baseline to 1-year follow-up | ||||||
| Overall HF | 55,845 | 4.19 | 0.75 (0.61, 0.93) |
0.007 | 0.77 (0.62, 0.95) |
0.02 |
| HFpEF | 55,713 | 2.08 | 0.62 (0.46, 0.83) |
0.002 | 0.61 (0.44, 0.83) |
0.002 |
| HFrEF | 55,713 | 1.72 | 0.86 (0.62, 1.18) |
0.34 | 0.89 (0.64, 1.24) |
0.49 |
Multivariable adjusted Cox proportional hazard models were constructed for each continuous measure of body composition and for each HF outcome with sequential adjustment for potential confounders
Model 1 included age, sex, race/ethnicity, education, income, treatment group, baseline CRF, history of hypertension, systolic BP, smoking status, alcohol use status, estimated GFR, diabetes duration, insulin use, HbA1c, history of CVD
Model 2 included Model 1 covariates plus year 1 percent change in predicted fat mass (except for WC model), year 1 percent change in predicted lean mass (except for WC model), year 1 percent change in HbA1c, year 1 percent change in systolic BP
Abbreviations: BP = blood pressure; CI = confidence interval; CRF = cardiorespiratory fitness; CVD = cardiovascular disease; GFR = glomerular filtration rate; HbA1c = glycated hemoglobin; HF = heart failure; HFpEF = heart failure with preserved ejection fraction; HFrEF = heart failure with reduced ejection fraction; HR = hazard ratio; WC = waist circumference