TABLE 2.
Association between CQ/HCQ exposure during pregnancy and the risk of prematurity.
| Prematurity (<37 weeks of gestation) | ||||
|---|---|---|---|---|
| Variables | Yes n = 15,676 | No n = 218,072 | Crude OR (95% CI) | Adjusted OR (95% CI) |
| n (%) | ||||
| Study medication exposures: | ||||
| During the 1st trimester: | ||||
| CQ/HCQ | 23 (0.15) | 195 (0.09) | 1.62 (1.03–2.53) | 1.39 (0.84–2.30) |
| Other antimalarial medicationsa | 10 (0.06) | 119 (0.05) | 1.21 (0.57–2.57) | 1.22 (0.59–2.54) |
| During the 2nd/3rd trimesters: | ||||
| CQ/HCQ | 15 (0.10) | 144 (0.07) | 1.13 (0.65–1.96) | 0.87 (0.46–1.67) |
| Other antimalarial medicationsa | 3 (0.02) | 53 (0.02) | 0.76 (0.23–2.59) | 0.77 (0.23–2.53) |
| Maternal age at the 1DGb - mean (SD) | 28.11 ± 5.91 | 28.23 ± 5.57 | 1.00 (0.99–1.00) | 1.00 (1.00–1.00) |
| Adherent vs. welfare recipient | 10,917 (69.64) | 169,420 (77.69) | 0.68 (0.65–0.70) | 0.73 (0.70–0.76) |
| Urban dweller | 12,924 (82.44) | 179,556 (82.34) | 1.01 (0.97–1.05) | 0.96 (0.92–1.01) |
| Diagnosis during pregnancy for: | ||||
| SLEc | 25 (0.16) | 150 (0.07) | 2.39 (1.56–3.66) | 1.95 (1.23–3.07) |
| Malaria | 5 (0.03) | 55 (0.03) | 1.38 (0.58–3.30) | 1.22 (0.50–2.96) |
| Rheumatoid arthritis | 29 (0.18) | 405 (0.19) | 1.00 (0.68–1.46) | 0.83 (0.57–1.21) |
| Comorbidities in the year prior to the 1DG: | ||||
| Hypertension | 666 (4.25) | 5,321 (2.44) | 1.66 (1.53–1.81) | 1.44 (1.32–1.57) |
| Diabetes | 620 (3.96) | 4,684 (2.15) | 1.80 (1.64–1.97) | 1.53 (1.40–1.67) |
| Asthma | 2,273 (14.50) | 26,000 (11.92) | 1.21 (1.16–1.27) | 1.05 (1.00–1.10) |
| Thyroid disorders | 744 (4.75) | 9,637 (4.42) | 1.07 (0.99–1.16) | 0.97 (0.90–1.05) |
| Diagnosis of dependence to: | ||||
| Tobacco | 851 (5.43) | 6,527 (2.99) | 1.77 (1.64–1.91) | 1.53 (1.41–1.65) |
| Alcohol | 124 (0.79) | 805 (0.37) | 2.04 (1.67–2.48) | 1.11 (0.90–1.37) |
| Other drugs | 372 (2.37) | 2,021 (0.93) | 2.44 (2.17–2.74) | 1.82 (1.61–2.06) |
| HIV drugd use during the 1st trimester | 32 (0.20) | 174 (0.08) | 1.70 (0.86–3.36) | 1.59 (0.80–3.15) |
| HIV drug use during the 2nd/3rd trimesters: | 45 (0.29) | 288 (0.13) | 1.51 (0.84–2.72) | 1.22 (0.67–2.20) |
| In the year prior to the 1DG: | ||||
| Emergency visit or hospitalization | 6,143 (39.19) | 73,357 (33.64) | 1.24 (1.20–1.28) | 1.07 (1.03–1.11) |
| General practitioner visit | ||||
| 0 | 2,980 (19.01) | 46,459 (21.30) | Ref. | Ref. |
| 1–3 | 5,521 (35.22) | 82,944 (38.04) | 1.03 (0.99–1.08) | 0.99 (0.95–1.04) |
| 4 or more | 7,175 (45.77) | 88,669 (40.66) | 1.22 (1.17–1.28) | 1.05 (1.00–1.11) |
| Specialist visits | ||||
| 0 | 5,539 35.33) | 86,194 (39.53) | Ref. | Ref. |
| 1–2 | 3,652 (23.30) | 54,547 (25.01) | 1.04 (0.99–1.08) | 0.98 (0.93–1.02) |
| 3 or more | 6,485 (41.37) | 77,331 (35.46) | 1.27 (1.23–1.32) | 1.08 (1.03–1.13) |
| Other prescribed medicationse | ||||
| 0 | 4,003 (25.54) | 65,646 (30.10) | Ref. | Ref. |
| 1–2 | 5,072 (32.36) | 74,926 (34.36) | 1.11 (1.07–1.16) | 1.07 (1.03–1.12) |
| 3 or more | 6,601 (42.11) | 77,500 (35.54) | 1.36 (1.30–1.41) | 1.14 (1.09–1.20) |
| Pregnancy follow-up by obstetrician | 9,585 (61.14) | 124,108 (56.91) | 1.19 (1.15–1.24) | 1.19 (1.14–1.23) |
| Pregnancy in the year prior the 1DG | 1,495 (9.54) | 18,610 (8.53) | 1.12 (1.06–1.18) | 0.98 (0.93–1.04) |
| Folic acid consumption before the end of the 1st trimester | 772 (4.92) | 8,000 (3.67) | 1.33 (1.23–1.44) | 1.16 (1.07–1.26) |
Atovaquone, mefloquine, primaquine, proguanil, sulfadoxine-pyrimethamine, and halofantrine.
First day of gestation defined as the first day of the last menstrual period (LMP).
Systemic lupus erythematosus.
Alone or combined: abacavir, adefovir dipivoxil, atazanavir, AZT, bictegravir, cobicistat, darunavir, delavirdine, didanosine, dolutegravir, doravirine, efavirenz, elvitegravir, emtricitabine, enfuvirtide, etravirine, fosamprenavir, indinavir, lamivudine, lopinavir, maraviroc, nelfinavir, nevirapine, raltegravir, retrovir, rilpivirine, ritonavir, saquinavir, stavudine, tenofovir disoproxil, tenofovir alafenamide, tipranavir, and zidovudine.
Other prescribed medications than the study medications and medications used to assess the maternal co-morbidities prior pregnancy.