Table 2.
Histopathologic Characterization of SARS-CoV-2-Infected (5×105 TCID50) Hamster Lung
| Pathological Finding | -: No Observation, +: Mild, ++: Severe |
|---|---|
| Edema | + |
| Consolidation (pneumonia and bronchopneumonia) | + |
| Alveolar hemorrhage | + |
| Diffuse exudative alveolar injury | ++ |
| Alveolar hyaline membrane | + |
| Inflammation | + |
| Necrosis and septal destruction | - |
| Pneumocyte shedding | + |
| Eosinophilic inclusion in pneumocytes | - |
| Pneumocyte transformation to multinucleated giant cells | + |
| Alveolar epithelial hyperplasia | ++ |
| Alveolar wall thickening and extracellular matrix deposition | + |
| Neutrophilic capillaritis | - |
| Pulmonary fibrosis | - |