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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Stroke. 2021 Jun 23;52(8):2661–2670. doi: 10.1161/STROKEAHA.120.032042

Figure 4. Equol decreased mRNA expression of pro-inflammatory cytokines in ovariectomized female mice.

Figure 4.

There was a trend of reduction in IL-1β and IL-6 expression levels 3 days after aneurysm induction in the equol-treated mice relative to controls (upper panel). At 5 days of post-aneurysm induction, mRNA level of IL-6 was significantly lower in equol-treated mice compared to vehicle (lower panel, * P < 0.05). There was a tendency for reduced IL-1β and TNFα levels in the equol-treated mice compared to vehicle-treated animals, though this difference did not achieve statistical significance.