Table 2. Vaccine effectiveness against SARS-CoV-2 infection and other COVID-19 associated outcomes in Minnesota.

Incidence is calculated as the number of individuals experiencing the given outcome per 1000 at-risk person-days. The columns are: (1) Time Period: Time period relative to first or second vaccine dose; (2) Outcome: The defined COVID-19 related outcome, including a positive SARS-CoV-2 test or COVID-19 associated hospitalization, ICU admission, or death. (3–5) Incidence Rates: Number of individuals with in the cohort experiencing the outcome in the time period, divided by the number of at-risk person-days for the cohort in the time period; in brackets and parentheses, the number of cases per 1000 person-days and the number of individuals contributing at-risk person-days. (6–8) Incidence Rate Ratio: Incidence Rate of the given vaccinated cohort divided by the Incidence Rate of the unvaccinated cohort, along with the exact 95% confidence interval. Vaccine effectiveness is calculated as 100 × (1-IRR). (8) Incidence Rate Ratio: Incidence Rate of the mRNA-1273 cohort divided by the Incidence Rate of the BNT=162b2 cohort, along with the exact 95% confidence interval.¹²

Time Period	Outcome	mRNA-1273 Incidence Rate Events/Person-Days [Per 1000 Person-Days] (# Individuals Contributing)	BNT162b2 Incidence Rate Events/Person-Days [Per 1000 Person-Days] (# Individuals Contributing)	Unvaccinate d Incidence Rate Events/Person-Days [Per 1000 Person-Days] (# Individuals Contributing)	IRR mRNA-1273 / Unvax	IRR BNT162b2 / Unvax	IRR mRNA-1273 / BNT162b2
Days 1–7 following first dose	Positive SARS-CoV-2 PCR Test	74/180810 [0.41] (n = 25869)	58/180675 [0.32] (n = 25869)	69/180614 [0.38] (n = 25869)	1.1 (0.76, 1.5)	0.84 (0.58, 12)	1.3 (0.89, 1.8)
	COVID-19 Associated Hospitalization	6/180937 [0.033] (n = 25869)	2/180812 [0.011] (n = 25869)	8/180798 [0.044] (n = 25869)	0.75 (0.21, 2.5)	0.25 (0.026, 13)	3 (0.54, 30)
	COVID-19 Associated ICU Admission	0/180951 [0] (n = 25869)	0/180814 [0] (n = 25869)	2/180812 [0.011](n = 25869)	0 (0, 5.3)	0 (0, 5.3)	N/A
	COVID-19 Associated Death	0/180951 [0] (n = 25869)	0/180814 [0] (n = 25869)	0/180819 [0] (n = 25869)	N/A	N/A	N/A
On or after 14 days following the second dose	Positive SARS-CoV-2 PCR Test	38/2214873.0 [0.017] (n = 21179)	72/2332005.0 [0.031] (n = 22064)	321/2526895.0 [0.13] (n = 24990)	0.14 (0.094, 0.19)	0.24 (0.19, 0.31)	0.56 (0.36, 0.83)
	COVID-19 Associated Hospitalization	6/2215483.0 [0.0027] (n = 21187)	11/2333145.0 [0.0047] (n = 22085)	82/2532948.0 [0.032] (n = 25083)	0.084 (0.03, 0.19)	0.15 (0.07, 0.27)	0.57 (0.17, 1.7)
	COVID-19 Associated ICU Admission	1/2215536.0 [0.00045] (n = 21187)	2/2333352.0 [0.00086] (n = 22090)	17/2534192.0 [0.0067] (n = 25097)	0.067 (0.0016, 0.43)	0.13 (0.014, 0.54)	0.53 (0.0089, 10)
	COVID-19 Associated Death	0/2215773.0 [0] (n = 21187)	0/2333860.0 [0] (n = 22092)	4/2537030.0 [0.0016] (n = 25101)	0 (0, 1.7)	0 (0, 1.6)	N/A