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[Preprint]. 2021 Oct 29:2021.08.08.21261763. Originally published 2021 Aug 9. [Version 3] doi: 10.1101/2021.08.08.21261763

Figure 2: Neuro-PASC reactivity to SARS-CoV-2 N and M peptides compared to healthy COVID convalescents.

Figure 2:

A-B.) NP (PCR+ or seropositive Neuro-PASC) and CC (PCR+ or seropositive healthy COVID convalescent) groups display similar IFN-γ and IL-2 responses to peptides from SARS-CoV-2 Spike protein by ELISPOT. C-D.) NP samples show significantly enhanced IFN-γ responses to the N3 peptide pool (C) and to the M1 and M3 peptide pools (D) compared with CC or HC. E-F.) N- and M- specific IL-2 production did not significantly differ between subject groups. G.) Spike RBD IgG endpoint titer quantification for NP, CC, and HC groups. LOD = limit of detection. Data representative of 10 experiments with all conditions plated in duplicate. *p<0.05, **p<0.01, ***p<0.005, ****p<0.0001 by two-way ANOVA with Tukey’s posttest.