Figure 1: Biophysical and functional antibody responses among convalescent donors.

A. Heatmap of filtered and hierarchically clustered SARS-CoV-2-specific Fc array features across disease severity and infection status in the JHMI cohort. Each row represents an individual subject, and subjects are grouped by disease status, as indicated by the vertical color bar. Each column represents an Fc array feature; horizontal color bars indicate each function or each Fv-specificity and Fc-characteristic tested. Responses are scaled and centered per feature and the range was truncated +/− 3 SD. Higher responses are indicated in red and lower responses are indicated in blue. Missing data is indicated in light gray. B. Weighted network plots of correlative relationships (|r| > 0.5) among antibody functions (black) and CoV-2-specific antibody features. Fc array measurements are colored by Fc characteristic and Fv specificity is indicated in text label (R = RBD).