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[Preprint]. 2021 Aug 8:2021.08.06.21261710. [Version 1] doi: 10.1101/2021.08.06.21261710

Figure 4: Experimental validation of IgM-mediated neutralization.

Figure 4:

A. Median fluorescent intensity (MFI) levels of RBD-specific IgG, IgA, IgM observed pre- (filled circles) and post-(hollow squares) IgM depletion. Mean fold change in MFI across samples for each isotype is indicated below the figure. B. Neutralization titers pre- and post-IgM depletion. C. Comparison of RBD-specific Ig levels to neutralization titer. Statistical significance (two-tailed p value) of Spearman correlation coefficients reported in inset.