Table 1.
Demographics and Candidate Predictors From Clinical Evaluation and Diagnostic Imaging/Testing of Human Immunodeficiency Virus–Uninfected Participantsa
| Children, No. (%)b | ||
|---|---|---|
| Variable | Tuberculosis (n = 242) | Not Tuberculosis (n = 236) |
| Demographics | ||
| Sex | ||
| Male | 127 (52) | 128 (54) |
| Female | 115 (48) | 108 (46) |
| Age, median (IQR), mo | 18.09 (10.14–32.1) | 15.28 (9.36–27.52) |
| Age group, y | ||
| 0–1 | 15 (64) | 161 (68) |
| 2–4 | 60 (25) | 62 (26) |
| ≥5 | 27 (11) | 13 (6) |
| Weight-for-age z score , median (IQR) | −1.71 (−3.01 to −0.66) | −1.46 (−2.47 to −0.69) |
| Weight-for-age z score below −2 | 105 (43) | 92 (39) |
| Clinical history at baseline | ||
| Cough duration, wk | ||
| No cough | 46 (19) | 55 (23) |
| <1 | 74 (31) | 97 (41) |
| 1–2 | 43 (18) | 32 (14) |
| 2–3 | 23 (1) | 16 (7) |
| >3 | 56 (23) | 36 (15) |
| Fever | 147 (61) | 105 (44) |
| Failure to thrive/weight loss | 111 (46) | 87 (37) |
| Poor appetite | 137 (57) | 122 (52) |
| Lethargy | 104 (43) | 74 (31) |
| History of tuberculosis contact | 128 (53) | 55 (23) |
| Clinical examination at baseline | ||
| Lymphadenopathy | 151 (62) | 145 (61) |
| Stridor | 6 (2) | 3 (1) |
| Wheeze | 55 (23) | 58 (25) |
| Hepatomegaly | 42 (17) | 19 (8) |
| Splenomegaly | 19 (8) | 6 (3) |
| Diagnostic testing/imaging at baseline | ||
| CR findings consistent with pulmonary tuberculosis at baseline | 131 (54) | 22 (9) |
| Xpert-confirmed Mycobacterium tuberculosis on respiratory specimens at baseline | 62 (26) | 0 (0) |
| Retrospective clinical case definitions | ||
| Confirmed tuberculosis | 104 (43) | 0 (0) |
| Unconfirmed tuberculosis | 138 (57) | 0 (0) |
| Unlikely tuberculosis | 0 (0) | 236 (0) |
Abbreviations: CR, chest radiography; IQR, interquartile range; Xpert, Xpert MTB/RIF assay.
aParticipants with sufficiently complete data for this analysis.
bData represent no. (%) of participants, unless otherwise identified as median (IQR).