Table 2.

Suggestive^a Signals Associated with Susceptibility to Trypanosoma cruzi Infection in the Colombian Cohort

Chr	Locus	Bp	SNP	SNP status	Rsq	Effect allele	Allele Freq	P -value	OR (95% CI)	Function
1	CD247	167431884	rs554994388	Imputed	0.50	G	0.03	5.35E-07	1.33 (1.19–1.49)	Intronic
8	EBF2	25979367	rs147475322	Imputed	0.86	A	0.03	2.15E-07	1.20 (0.76–1.90)	Intronic
11	IL18	112127040	rs4937075	Imputed	0.77	C	0.77	8.34E-07	1.02 (0.86–1.21)	Intergenic
21	SIK1	43428190	rs229347	Imputed	0.88	A	0.60	8.93E-07	1.07 (1.04–1.10)	Intergenic

^aSuggestive associations were considered with a P-value ≤ 1E-06

Associated loci were determined in order to the LD of contained variants and the most significant SNP of each loci were reported in the table.

The r-squared metric (Rsq) indicates the correlation between input genotypes and imputed dosages.

Abbreviations: Allele Freq, allele frequency; bp, base pair; chr, chromosome; CI, confidence interval; OR, odds ratio; SNP info, SNP information.