Table 3.
Genome-Wide Significant Association and Suggestivea Signals Associated with Chronic Chagas Cardiomyopathy Development in the Meta-Analysis
| Chr | Locus | Bp | SNP | SNP status | Rsq | Effect allele | Allele Freq | P-value Q | P -value | OR (95% CI) | Function |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | CDH8 | 18718887 | rs10472156 | Imputed | 0.81 | A | 0.73 | .72 | 8.89E-07 | 1.10 (1.06–1.14) | Intergenic |
| 9 | KLF4 | 107479876 | rs10759240 | Genotyped | - | C | 0.54 | .98 | 4.68E-07 | 0.92 (0.89–0.95) | Intergenic |
| 11 | SAC3D1 | 65047341 | rs2458298 | Imputed | 0.95 | G | 0.26 | .98 | 3.27E-08 | 0.90 (0.87–0.94) | Intronic |
aSuggestive associations were considered with a P-value ≤ 1E-06
Associated loci were determined in order to the LD of contained variants and the most significant SNP of each loci were reported in the table.
In boldface the genome-wide significant signal.
The r-squared metric (Rsq) indicates the correlation between input genotypes and imputed dosages.
Abbreviations: Allele Freq, allele frequency; bp, base pair; chr, chromosome; CI, confidence interval; OR, odds ratio; P-value Q Cochran’s Q test; rsq, r-square; SNP info, SNP information.