Table 4.

In Silico Functional Analysis of the Associated Variant with Chronic Chagas Cardiomyopathy Development

Chr	SNP	Nearest gene	eQTLs	C-HiC Genes	PheWAS
11	rs2458298	SAC3D1 NAALADL1	SNX15 a	BATF2 in GM12878b	Hypertension, high blood pressure and abdominal aortic aneurysm
			FERMT3 b

^aeGENE in heart atrial appendage and heart left ventricle

^blymphoblastoid cell line

Queried data bases were Open Targets Genetics, GTEx, RegulomeDB, Capture HiC Plotter, and PheWEB

Abreviations: Chr, chromosome; C-HiC, capture Hi-C; eQTL, expression quantitative trait loci; PheWAS, phenome-wide association study; SNP, single nucleotide polymorphism.