Table 3.

Linear Regressions Predicting Brain Volumes Across All Participants After 1, 3 and 5 Years of Intervention Based on Baseline CRF

	Hippocampus			Thalamus			Caudate			Cortex			White Matter
	β	CI	p	β	CI	p	β	CI	p	β	CI	p	β	CI	p
1 year
CRF at baseline	0.02	−0.00, 0.05	0.055	0.00	−0.03, 0.03	0.796	0.01	−0.02, 0.04	0.599	1.47	0.67, 2.28	<0.001	−1.52	−4.16, 1.12	0.256
3 years
CRF at baseline	0.02	−0.00, 0.05	0.085	−0.00	−0.03, 0.03	0.867	0.01	−0.02, 0.04	0.651	1.16	0.33, 2.00	0.007	−1.14	−3.90, 1.61	0.411
5 years
CRF at baseline	0.02	−0.01, 0.05	0.112	0.00	−0.03, 0.03	0.899	0.01	−0.02, 0.04	0.576	1.17	0.31, 2.04	0.009	−0.87	−3.84, 1.92	0.564

Notes: p-values <0.05 are in bold font. Beta (β) is the estimated regression coefficient, CI is the 95% confidence interval. Brain volumes are included in the model as mL. The analysis is corrected for age at baseline, sex and education. Brain volumes were corrected for intracranial volume (ICV) using the residual method.

Abbreviation: CRF, cardiorespiratory fitness measured as VO_2peak.