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. 2021 Aug 12;13:6377–6387. doi: 10.2147/CMAR.S320490

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© 2021 Mao et al.

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βKlotho overexpression down-regulated the expression of ELK4, and the elevated βKlotho expression inhibited the proliferation of C4-2B cell line, which can be reversed by the overexpression of ELK4. The C4-2B cell line was transfected with empty vector (GV230-CON083), GV230-βKlotho (βKlotho) or GV230-βKlotho plus GV230-ELK4 plasmids (βKlotho+ELK4). (A) The Western blotting assay. (B) The CCK-8 assay. (C) The colony formation assay. *p < 0.05, **p < 0.01.

Abbreviations: ELK4, ETS-like transcription factor 4; PARP, poly ADP-ribose polymerase; EV, empty vector.