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. 2021 Aug 12;13:6377–6387. doi: 10.2147/CMAR.S320490

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© 2021 Mao et al.

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βKlotho overexpression down-regulated the expression of ELK4, and the elevated βKlotho expression inhibited the proliferation of PC3 cell line, which can be reversed by the overexpression of ELK4. The PC3 cell line was transfected with empty vector (GV230-CON083), GV230-βKlotho (βKlotho) or GV230-βKlotho plus GV230-ELK4 plasmids (βKlotho+ELK4). (A) The Western blotting assay. (B) The CCK-8 assay. (C) The colony formation assay. **p < 0.01.

Abbreviations: ELK4, ETS-like transcription factor 4; PARP, poly ADP-ribose polymerase; EV, empty vector.