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. 2021 Aug 2;18(8):e1003708. doi: 10.1371/journal.pmed.1003708

Table 3. Numbers of incident cases and PPVs (95% CIs) for the composite outcome of either cancer or IBD in the year following each studied abdominal symptom.

Men Women
Number diagnosed with either cancer or IBD PPV (%) (95% CI) Number diagnosed with either cancer or IBD PPV (%) (95% CI)
Abdominal bloating/distension 739 2.71 (2.52, 2.90) 1,707 2.32 (2.21, 2.43)
    Combined with the following:
    Abdominal pain 180 4.13 (3.54, 4.72) 401 3.26 (2.95, 3.58)
    Change in bowel habit 17 3.75 (2.00, 5.50) 37 3.83 (2.62, 5.05)
    Dyspepsia 453 2.42 (2.20, 2.64) 1,028 1.98 (1.86, 2.10)
    Dysphagia <14 <6.09 14 2.65 (1.28, 4.01)
    Rectal bleeding 35 5.31 (3.60, 7.02) 54 4.21 (3.11, 5.31)
Abdominal pain 9,607 2.92 (2.86, 2.98) 13,198 2.35 (2.31, 2.39)
    Combined with the following:
    Abdominal bloating/distension 115 4.05 (3.33, 4.78) 247 3.19 (2.80, 3.59)
    Change in bowel habit 212 7.57 (6.59, 8.55) 241 5.24 (4.60, 5.89)
    Dyspepsia 542 3.25 (2.98, 3.52) 780 2.82 (2.63, 3.02)
    Dysphagia 78 4.73 (3.71, 5.75) 120 4.13 (3.41, 4.86)
    Rectal bleeding 390 6.70 (6.06, 7.34) 381 4.92 (4.44, 5.40)
Change in bowel habit 3,353 7.41 (7.17, 7.65) 3,015 4.90 (4.73, 5.08)
    Combined with the following:
    Abdominal bloating/distension 27 5.56 (3.52, 7.59) 53 4.31 (3.18, 5.45)
    Abdominal pain 321 7.27 (6.50, 8.03) 379 4.58 (4.13, 5.03)
    Dyspepsia 118 5.27 (4.35, 6.20) 179 4.67 (4.01, 5.34)
    Dysphagia 23 7.32 (4.44, 10.21) 22 4.59 (2.72, 6.47)
    Rectal bleeding 212 14.81 (12.97, 16.66) 188 10.02 (8.66, 11.38)
Dyspepsia 4,983 2.29 (2.23, 2.36) 6,063 2.02 (1.97, 2.07)
    Combined with the following:
    Abdominal bloating/distension 393 2.50 (2.26, 2.75) 905 2.01 (1.88, 2.14)
    Abdominal pain 632 2.90 (2.68, 3.13) 927 2.45 (2.29, 2.61)
    Change in bowel habit 63 3.90 (2.95, 4.84) 85 3.34 (2.64, 4.04)
    Dysphagia 142 3.10 (2.60, 3.60) 136 2.85 (2.38, 3.32)
    Rectal bleeding 141 3.65 (3.06, 4.25) 160 3.84 (3.26, 4.43)
Dysphagia 1,874 5.01 (4.79, 5.23) 1,474 3.02 (2.87, 3.18)
    Combined with the following:
    Abdominal bloating/distension <10 <4.50 <15 <2.38
    Abdominal pain 150 6.22 (5.26, 7.19) 171 3.38 (2.89, 3.88)
    Change in bowel habit <20 <7.14 16 3.69 (1.91, 5.46)
    Dyspepsia 167 6.37 (5.44, 7.31) 132 3.19 (2.66, 3.73)
    Rectal bleeding 36 5.85 (4.00, 7.71) 26 3.61 (2.25, 4.97)
Rectal bleeding 6,768 5.80 (5.66, 5.93) 6,128 5.18 (5.05, 5.30)
    Combined with the following:
    Abdominal bloating/distension 39 6.44 (4.48, 8.39) 69 4.85 (3.73, 5.96)
    Abdominal pain 414 5.41 (4.90, 5.92) 614 4.77 (4.40, 5.13)
    Change in bowel habit 176 13.31 (11.48, 15.14) 204 11.76 (10.25, 13.28)
    Dyspepsia 218 4.74 (4.12, 5.35) 251 4.42 (3.88, 4.95)
    Dysphagia 25 4.20 (2.59, 5.81) 46 6.01 (4.32, 7.69)

Total counts of cancer or IBD, where counts of cancer <5 or of IBD <5 in Table 2, are not presented here (in Table 3) in compliance with reporting standards for minimising disclosivity risk.

CI, confidence interval; IBD, inflammatory bowel disease; PPV, positive predictive value.