Table 1.

List of current heart failure with preserved ejection fraction (HFpEF) animal models with coexistence of metabolic phenotype.

Animal model	Phenotype	References
FPR2KO	✓ Obesity ✓ Cardiac dysfunction ✓ Aging ✓ Renal dysfunction ✓ Systemic inflammation ✓ Immunometabolism dysfunction Hypertension? Diabetes?	Mouse (28, 52)
HFD+L-NAME	✓ Obesity ✓ Hypertensive stress ✓ Systemic inflammation ✓ Cardiac dysfunction ✓ Hypertension Aging? Renal dysfunction? Immunometabolism dysfunction?	Mouse (53)
Ob/ob or db/db	✓ Obesity ✓ Diabetes phenotype Aging? Renal dysfunction? Systemic inflammation? Immunometabolism dysfunction?	Mouse (54, 55)
ZF/ZDF	✓ Obesity ✓ Diabetes phenotype Cardiac dysfunction? Renal dysfunction? Aging? Systemic inflammation? Immunometabolism dysfunction?	Rat (56, 57)
SKO	✓ Diabetes phenotype ✓ Cardiomegaly ✓ Cardiac dysfunction Aging? Obesity? Hypertension? Immunometabolism dysfunction?	Mouse (58)
Dahl salt-sensitive and ZSF1 models	✓ Obesity ✓ Aging ✓ Hypertension ✓ Metabolism dysfunction ✓ Cardiac dysfunction Systemic inflammation? Renal dysfunction?	Rat (59)

(v) indicates experimental animal model that recapitulate HFpEF aspects. (?) indicates that the experimental animal model has not been studied for the indicated aspect. FPR2KO, formyl peptide receptor 2 knock out; Ob/Ob, obese mouse; db/db, db gene knock out, responsible for leptin receptor; ZF/ZDF, Zucker fatty/Zucker diabetic fatty; SKO, seipin knock out; ZSF1, Zucker spontaneously fatty hypertensive heart failure F1 hybrid.