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. Author manuscript; available in PMC: 2022 Jun 16.
Published in final edited form as: J Am Chem Soc. 2021 Jun 7;143(23):8689–8703. doi: 10.1021/jacs.1c02456

Scheme 3. Synthetic route to 6a.

Scheme 3.

aReagents and conditions. (a) (COCl)2, DMSO, TEA, THF, –78 °C-rt; (b) Deoxo-Fluor (2.7 M in toluene), THF, 120 °C (MW); (c) ceric ammonium nitrate, CH3CN/H2O, rt; (d) i) HCl (1.2 M in MeOH), 85 °C, seal; ii) Boc2O, MeOH, rt; (e) Burgess reagent, THF, 70 °C; (f) 4N HCl, AcOH, 70 °C.