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. 2021 Aug 16;23(5):100. doi: 10.1208/s12248-021-00626-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Accumulation of peptide-modified nanoparticles in dissociated organs 1 h after administration (a) and representative surface fluorescent images (n = 5, mean ± SEM; one-way ANOVA with Bonferroni post-test compared to control nanoparticles, *p < 0.05, **p < 0.01, ****p < 0.0001) (b). Representative surface fluorescent images (c) and accumulation of peptide-modified nanoparticles in dissociated brain tissue, separated by injured and contralateral hemispheres, 1 h after administration (d). Relative amounts of nanoparticle signal in the injured vs. contralateral uninjured hemisphere (n = 5, mean ± SEM; two-tailed t test between injured and uninjured groups, ^#p < 0.1, **p < 0.01) (e)