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The structure of DSP. The three isoforms differ in the length of the central rod domain (Rod). The C-Tail contains three PRDs (A–C) and a GSR domain that is thought to regulate DSP binding to IFs. The amino-terminal globular head domain (Head) mediates protein–protein interactions. C-Tail: Carboxy-terminal tail; GSR: Glycine–serine–arginine rich; DSP: Desmoplakin; IF: Intermediate filaments; PRDs: Plakin repeat domains.
