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The Wnt/β-catenin pathway. When PKG translocates from desmosomes to the nucleus, it competes with β-catenin for binding to the TCF7L2/LEF1 transcription factors, leading to suppression of the Wnt pathway, which means an increase in adipogenesis and fibrosis and adipogenesis and a decrease in myogenesis. GSK3β: Glycogen synthase kinase-3 beta; PKG: Plakoglobin; TCF/LEF: T-cell factor/lymphoid enhancer factor.
