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. 2021 Aug 2;12:711734. doi: 10.3389/fpsyt.2021.711734

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Copyright © 2021 Sun, Zhao, Bo, Mao, He, Jiang, Li, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-related changes of plasma levels of oxysterols in schizophrenia (SCZ) patients, clinically high risk (CHR) individuals, and healthy controls (HC). (A,B) Absolute values of 24OHC at different ages; (C,D) Absolute values of 27OHC at different ages. (E,F) Ratio of 24OHC and 27OHC at different ages. Significant age-dependent decreases of 24OHC levels and 24OHC/27OHC values were found in the HCs. Opposite trend of 24OHC levels and 24OHC/27OHC values along with age were found between HCs and CHR individuals or SCZ patients, and the largest difference occurs before 25 years old. Plasma 27OHC levels showed significant age-dependent decrease in the SCZ group. Unlike 24OHC, the difference in 27OHC between patients and HCs became more and more significant with the increase of age.