Table 3.
NRI and IDI Analyses for Risk Reclassification of in Hospital Mortality in Original Cohort and Matched Cohort
| Outcome | Sensibility (%) | Specificity (%) | AUC | IDI | NRIa | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Biomaker | Biomaker+Clinical Model | Clinical Modelb | P valuec | Value (95% CI) | P value | Value (95% CI) | P value | |||
| Original Cohort | ||||||||||
| LMR | 65.0 | 67.3 | 0.706 | 0.795 | 0.751 | <0.001 | 0.021(0.003–0.045) | 0.020 | 0.121(0.014–0.214) | <0.001 |
| SOFA | 60.8 | 62.9 | 0.658 | 0.793 | 0.086 | −0.002(−0.007–0.005) | 0.515 | −0.023(−0.124–0.062) | 0.614 | |
| LMR+SOFA | 60.6 | 72.0 | 0.710 | 0.798 | 0.001 | 0.018(0.001–0.045) | 0.045 | 0.110(0.001–0.216) | 0.030 | |
| Matched 1cohort | ||||||||||
| LMR | 56.7 | 75.7 | 0.707 | 0.785 | 0.770 | 0.017 | 0.032(0.007–0.058) | <0.001 | 0.124(0.007–0.246) | 0.031 |
| SOFA | 60.9 | 65.5 | 0.671 | 0.777 | 0.054 | 0.012(−0.002–0.035) | 0.109 | 0.055(−0.060–0.176) | 0.259 | |
| LMR+SOFA | 63.3 | 69.4 | 0.714 | 0.799 | 0.013 | 0.032(0.010–0.057) | 0.011 | 0.104(0.001–0.249) | 0.045 | |
Notes: aThe NRI is calculated through two-way category by using the event rate of in hospital mortality, bThe clinical model for predicting in hospital mortality are composed of age, gender, weight, ethnicity, comorbidities, interventions, vital signs and laboratory results, cBiomarker+clinical model versus clinical model. It would be better if significant p values were expressed in bold characters.
Abbreviations: AUC, area under the receiver-operating characteristic curve; IDI, integrated discrimination improvement; NRI, net reclassification index; LMR, lymphocyte-to-monocyte ratio, SOFA, sequential organ failure assessment.