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. 2021 Aug 12;14:981–992. doi: 10.2147/JAA.S320088

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© 2021 Zou et al.

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Characterization of the gut microbiota in asthmatic patients. (A) The overall microbial composition was different between asthmatic and healthy groups (Adonis, p = 0.004). (B) Alpha-diversity of the intestinal microbiome was lower in asthmatic patients compared to control subjects by using Shannon indices (p = 0.031). (C) General landscape of gut microbiome in asthmatic patients and control subjects. (D) Differentially abundant bacterial communities between asthmatic patients and healthy control subjects by using LEfSe. (E–I) Species significantly enriched in asthmatic patients (E–G) and healthy controls (H and I) by using Student’s t-test. (J) ROC analysis of the bacterial biomarkers in RF model achieved an AUC of 0.964 to classify asthmatic patients from healthy controls. *, p < 0.05; **, p < 0.01.