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. 2021 Aug 12;14:981–992. doi: 10.2147/JAA.S320088

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© 2021 Zou et al.

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Distinct intestinal microbiotic community to mediate development of different asthma endotypes. (A) Integrated analysis of microbiome, clinical index and functional pathways in asthmatic patients with and without allergic history. (B) Correlation analysis between Clostridium disporicum (C. disporicum) and functional pathway of flavone and flavonol biosynthesis. (C) Clinical performance of C. disporicum and functional pathway for prediction of asthma. (D) Combination of C. disporicum, Flavonoid biosynthesis pathway and serum IL-4 level exhibited an AUC of 0.929 to classify asthmatic patients and healthy controls. (E) Correlation analysis between C. colinum and associated functional pathways. (F) Combination of C. colinum and its associated functional pathways resulted in an AUC of 0.780 to distinguish asthmatic patients with allergic history from non-allergic ones. *, p < 0.05; **, p < 0.01.