Table 2.
Characterizations of All Liposome Formulations
Sample | Size (nm) | PDI | Zeta Potential (mV) | Loading Capacity (%) | Loading Efficiency (%) |
---|---|---|---|---|---|
Lipo | 92.6 ± 0.9 | 0.212 ± 0.008 | −9.9 ± 0.45 | N/A | N/A |
AE-Lipo | 107.7 ± 1.3 | 0.196 ± 0.019 | −14.6 ± 0.22 | N/A | N/A |
DTX/Lipo | 108.3 ± 1.1 | 0.243 ± 0.003 | −12.3 ± 2.11 | 8.0 | 80 |
DTX/AE-Lipo | 129.5 ± 2.4 | 0.247 ± 0.007 | −14.2 ± 2.71 | 7.1 | 71 |
Ce6-Lipo | 124.9 ± 1.9 | 0.168 ± 0.024 | −15.1 ± 0.26 | N/A | N/A |
Ce6-AE-Lipo | 121.3 ± 1.9 | 0.189 ± 0.002 | −19.7 ± 0.67 | N/A | N/A |
Abbreviations: Lipo, non-targeting liposomes; AE-Lipo, targeting liposomes; DTX/Lipo, DTX-loaded liposomes; DTX/AE-Lipo, DTX-loaded targeting liposomes; Ce6-Lipo, Ce6-conjugated Lipo; Ce6-AE-Lipo, Ce6-conjugated AE-Lipo; N/A, Not available.