Table 2.
Results of logistic regression models predicting noncompletion of the study key endpoint.
| Variables | βa | SE | z value | P value | |||||||||
| Baseline demographics | |||||||||||||
|
|
Intercept | 1.633 | 0.509 | 3.209 | .001 | ||||||||
|
|
Age | –0.024 | 0.009 | –2.684 | .007 b | ||||||||
|
|
Gender (reference: male) | ||||||||||||
|
|
Female | –0.296 | 0.202 | –1.460 | .14 | ||||||||
|
|
Other | –0.181 | 1.172 | –0.155 | .88 | ||||||||
|
|
Educational level (reference: secondary education) | ||||||||||||
|
|
University degree | –0.574 | 0.206 | 2.786 | .005 | ||||||||
|
|
Primary education | –0.876 | 0.329 | –2.660 | .008 | ||||||||
|
|
Psychedelic advocacy | 0.031 | 0.027 | 1.124 | .26 | ||||||||
|
|
Psychological variables | ||||||||||||
|
|
Intercept | 2.355 | 1.293 | 1.822 | .07 | ||||||||
|
|
Depression (QIDSc) | 0.018 | 0.031 | 0.598 | .55 | ||||||||
|
|
Well-being (WEMWBSd) | –0.011 | 0.017 | –0.618 | .54 | ||||||||
|
|
Personality (TIPI) | ||||||||||||
|
|
Extraversion | 0.082 | 0.037 | 2.518 | .01 | ||||||||
|
|
Conscientiousness | –0.079 | 0.035 | –2.251 | .02 | ||||||||
|
|
Agreeableness | –0.018 | 0.041 | –0.446 | .66 | ||||||||
|
|
Emotional stability | 0.051 | 0.043 | 1.189 | .23 | ||||||||
|
|
Openness to experience | –0.044 | 0.052 | –0.848 | .40 | ||||||||
|
|
Trait anxiety (STAI-SFe) | –0.016 | 0.012 | –1.377 | .17 | ||||||||
|
|
Social connectedness (SCSf) | –0.007 | 0.012 | –0.646 | .52 | ||||||||
|
|
Trait absorption (MODTASg) | –0.000 | 0.007 | –0.080 | .94 | ||||||||
|
|
Suicidal ideation (SIDASh) | 0.013 | 0.016 | 0.831 | .41 | ||||||||
|
|
Delusional thinking (PDIi) | 0.035 | 0.029 | 1.196 | .24 | ||||||||
| Postacute timepoint (+1 day) | |||||||||||||
|
|
Intercept | –0.257 | 0.317 | –0.809 | .42 | ||||||||
|
|
Visual effects | 0.002 | 0.002 | 1.078 | .28 | ||||||||
|
|
Challenging experience (CEQj) | 0.001 | 0.007 | –0.117 | .91 | ||||||||
|
|
Ego dissolution (EDIk) | –0.010 | 0.006 | –1.535 | .13 | ||||||||
|
|
Mystical experience (MEQl) | 0.012 | 0.009 | 1.414 | .16 | ||||||||
|
|
Emotional breakthrough (EBIm) | –0.007 | 0.005 | –1.409 | .16 | ||||||||
|
|
Physical side-effects (PSIn) | –0.010 | 0.057 | –0.181 | .86 | ||||||||
|
|
Intercept for baseline–2-week changes | –1.590 | 2.312 | –0.688 | .49 | ||||||||
| Change scores (baseline to +2 weeks) | |||||||||||||
|
|
Depression (QIDS) | –0.014 | 0.062 | –0.221 | .83 | ||||||||
|
|
Psychological well-being (WEMWBS) | 0.012 | 0.026 | 0.457 | .65 | ||||||||
|
|
Trait anxiety (STAI-SF) | 0.027 | 0.024 | 1.137 | .26 | ||||||||
|
|
Social connectedness (SCS) | 0.026 | 0.019 | 1.413 | .16 | ||||||||
|
|
Delusional thinking (PDI) | 0.034 | 0.060 | 0.565 | .57 | ||||||||
| Baseline control variables | |||||||||||||
|
|
Depression (QIDS) | 0.022 | 0.056 | 0.411 | .68 | ||||||||
|
|
Psychological well-being (WEMWBS) | 0.001 | 0.029 | 0.028 | .98 | ||||||||
|
|
Trait anxiety (STAI-SF) | –0.014 | 0.021 | –0.667 | .51 | ||||||||
|
|
Social connectedness (SCS) | 0.019 | 0.018 | 1.019 | .31 | ||||||||
|
|
Delusional thinking (PDI) | 0.044 | 0.039 | 1.144 | .25 | ||||||||
aβ: estimated regression coefficient.
bItalicized values indicate significance levels of P<.05.
cQIDS: Quick Inventory of Depressive Symptomatology.
dWEMWBS: Warwick-Edinburgh Mental Well-being Scale.
eSTAI-SF: Spielberger State-Trait Anxiety Inventory.
fSCS: Social Connectedness Scale.
gMODTAS: modified version of the Tellegen Absorption Scale.
hSIDAS: Suicidal Ideation Attributes Scale.
iPDI: Peters’ Delusional Inventory.
jCEQ: Challenging Experience Questionnaire.
kEDI: Ego Dissolution Inventory.
lMEQ: Mystical Experience Questionnaire.
mEBI: Emotional Breakthrough Inventory.
nPSI: Physical Symptoms Inventory.