Table 5.
Discordant cases (between telepathology and final diagnoses).
Type | Sample source | Telepathology diagnosis | Final diagnosis | Annotation | |||||
False positivea | |||||||||
|
Case 1 | Lung/mediastinum | Poorly differentiated carcinoma | Immunoglobulin M–positive lymphoproliferative disease with alveolar epithelial atypical hyperplasia | Unlabeled immunohistochemistry results | ||||
|
Case 2 | Respiratory tract | Highly differentiated squamous cell carcinoma | Squamous papillary hyperplasia with local typical hyperplasia | Intractable case | ||||
|
Case 3 | Uterus | Endometrial complex hyperplasia, local atypical hyperplasia, focal canceration | Simple endometrial hyperplasia | N/Ab | ||||
|
Case 4 | Uterus | Papillary squamous cell carcinoma | High-grade SILc involving glands | A bleeding background on the section | ||||
False negatived | |||||||||
|
Case 1 | Female genital organs | Vulva: chronic inflammation with low-grade SIL Cervix: chronic inflammation with high-grade SIL |
Vulva: highly differentiated squamous cell carcinoma with local superficial infiltration (depth of infiltration <1 mm) Cervix: chronic cervicitis, focal high-grade SIL, and involving glands |
Unlabeled immunohistochemistry results | ||||
|
Case 2 | Skin | Chronic inflammation, squamous epithelial hyperplasia with hyperkeratosis and parakeratosis | Superficial spreading malignant melanoma | Intractable case | ||||
|
Case 3 | Uterus | Chronic inflammation, glandular hyperplasia | Minimal deviation adenocarcinoma | N/A | ||||
|
Case 4 | Uterus | Chronic cervicitis with focal high-grade SIL and involving glands | High-grade SIL involving glands and squamous cell carcinoma in situ | N/A | ||||
|
Case 5 | Thyroid | Adenomatous nodular goiter with fibrosis and chronic lymphocytic thyroiditis around | Follicular carcinoma | Unlabeled immunohistochemistry results | ||||
|
Case 6 | Urinary | Mucosal polypoid hyperplasia with atypical urothelial hyperplasia | High-grade urothelial carcinoma | N/A | ||||
|
Case 7 | Uterus | SIL | Squamous cell carcinoma | A bleeding background on the section |
aCases that were malignant in telepathology diagnosis but benign in final diagnosis were considered false positive.
bN/A: not applicable.
cSIL: squamous intraepithelial lesion.
dCases that were malignant in the final diagnosis but benign in telepathology diagnosis were considered false negative.