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. 2021 Jul 29;23(7):e23799. doi: 10.2196/23799

Table 5.

Discordant cases (between telepathology and final diagnoses).

Type Sample source Telepathology diagnosis Final diagnosis Annotation
False positivea

Case 1 Lung/mediastinum Poorly differentiated carcinoma Immunoglobulin M–positive lymphoproliferative disease with alveolar epithelial atypical hyperplasia Unlabeled immunohistochemistry results

Case 2 Respiratory tract Highly differentiated squamous cell carcinoma Squamous papillary hyperplasia with local typical hyperplasia Intractable case

Case 3 Uterus Endometrial complex hyperplasia, local atypical hyperplasia, focal canceration Simple endometrial hyperplasia N/Ab

Case 4 Uterus Papillary squamous cell carcinoma High-grade SILc involving glands A bleeding background on the section
False negatived

Case 1 Female genital organs Vulva: chronic inflammation with low-grade SIL
Cervix: chronic inflammation with high-grade SIL
Vulva: highly differentiated squamous cell carcinoma with local superficial infiltration (depth of infiltration <1 mm)
Cervix: chronic cervicitis, focal high-grade SIL, and involving glands
Unlabeled immunohistochemistry results

Case 2 Skin Chronic inflammation, squamous epithelial hyperplasia with hyperkeratosis and parakeratosis Superficial spreading malignant melanoma Intractable case

Case 3 Uterus Chronic inflammation, glandular hyperplasia Minimal deviation adenocarcinoma N/A

Case 4 Uterus Chronic cervicitis with focal high-grade SIL and involving glands High-grade SIL involving glands and squamous cell carcinoma in situ N/A

Case 5 Thyroid Adenomatous nodular goiter with fibrosis and chronic lymphocytic thyroiditis around Follicular carcinoma Unlabeled immunohistochemistry results

Case 6 Urinary Mucosal polypoid hyperplasia with atypical urothelial hyperplasia High-grade urothelial carcinoma N/A

Case 7 Uterus SIL Squamous cell carcinoma A bleeding background on the section

aCases that were malignant in telepathology diagnosis but benign in final diagnosis were considered false positive.

bN/A: not applicable.

cSIL: squamous intraepithelial lesion.

dCases that were malignant in the final diagnosis but benign in telepathology diagnosis were considered false negative.