Table.
Summary of patient demographics and treatments received that were not specific to secondary haemophagocytic lymphohistiocytosis by patient
Sex | Age, years | Notable comorbidities | Time from admission to secondary haemophagocytic lymphohistiocytosis diagnosis, days | Peak ferritin, μg/L | Mechanical ventilation | Inotropic support | Renal replacement therapy | Other treatments received | Final patient outcome (days to death or discharge) | |
---|---|---|---|---|---|---|---|---|---|---|
Patient 1 | Male | 40 | Acute lymphoblastic leukaemia | 28 | 76 225 | Yes | No | No | Piperacillin and tazobactam preparation, meropenem, and liposomal amphotericin B | Died (74) |
Patient 2 | Male | 28 | Recurrent pneumonias | 6 | 3164 | Yes | Yes | No | Cefuroxime | Died (7) |
Patient 3 | Male | 36 | Acute lymphoblastic leukaemia | 12 | 17 085 | No | No | No | Meropenem, liposomal amphotericin B, and filgrastim | Discharged (31) |
Patient 4 | Male | 36 | No medical history | 1 | 5736 | Yes | Yes | No | Potassium clavulanate and amoxicillin preparation | Discharged (16) |
Patient 5 | Female | 60 | Systemic lupus erythematosus | 3 | 12 402 | Yes | Yes | Yes | Glucocorticoids (ie, for systemic lupus erythematosus) | Died (42) |
Patient 6 | Male | 56 | Asthma | 3 | 9245 | Yes | Yes | No | Potassium clavulanate and amoxicillin preparation and meropenem | Discharged (43) |
Patient 7 | Male | 63 | Type 2 diabetes and atrial fibrillation | 0 | 17 790 | Yes | Yes | No | Potassium clavulanate and amoxicillin preparation and piperacillin and tazobactam preparation | Discharged (11) |
Patient 8 | Male | 54 | Asthma | 0 | 19 078 | Yes | Yes | Yes | Glucocorticoids, potassium clavulanate and amoxicillin preparation, piperacillin and tazobactam preparation, and meropenem | Died (32) |
Patient 9 | Male | 52 | Previous deep vein thrombosis | 1 | 12 607 | Yes | Yes | Yes | Piperacillin and tazobactam preparation, clarithromycin, meropenem, vancomycin, and ciprofloxacin | Discharged (96) |
Patient 10 | Female | 22 | Sickle cell trait | 9 | 45 864 | No | Yes | No | Piperacillin and tazobactam preparation, ciprofloxacin, clindamycin, metronidazole, meropenem, linezolid, ceftazidime, and fluconazole | Discharged (40) |