Table 3. Diagnostic yield of magnifying NBI applying UMEC for esophageal lesions.

	Sensitivity % (95 % CI)	Specificity % (95 % CI)	PPV % (95 % CI)	NPV % (95 % CI)	Accuracy % (95 % CI)	Kappa value (95 % CI) P value
E-UMEC 1 vs 2 + 3 (non-neoplastic vs neoplastic)
Endoscopist A	91.3 (77.4–97.4)	90.8 (85.8–92.9)	77.8 (65.9–83.0)	96.7 (91.5–99.0)	90.9 (83.6–94.1)	0.59 (0.40–0.77) P  < 0.0001
Endoscopist B	82.6 (67.9–91.5)	92.3 (87.1–95.5)	79.2 (65.1–87.7)	93.8 (88.5–97.0)	89.8 (82.1–94.4)
E-UMEC 1 + 2A vs 2B + 3 (non-cancer vs cancer)
Endoscopist A	73.3 (66.1–75.2)	97.7 (90.1–99.6)	97.1 (87.4–99.5)	77.8 (71.7–79.3)	85.2 (77.8–87.1)	0.51 (0.35–0.66) P  < 0.0001
Endoscopist B	95.6 (87.7–98.7)	72.1 (63.9–75.4)	78.2 (71.7–80/8)	93.9 (83.2–8.3)	84.1 (76.0–87.3)
E-UMEC 1 + 2 vs 3 (Deep submucosal invasive cancer vs others)
Endoscopist A	81.8 (56.3–94.6)	90.0 (87.3–92.7)	56.3 (38.7–65.0)	97.2 (93.3–99.2)	89.8 (83.4–93.0)	0.56 (0.32–0.80) P  < 0.0001
Endoscopist B	54.5 (33.6–62.0)	98.7 (95.7–99.8)	85.7 (52.8–97.4)	93.8 (91.0–94.8)	93.2 (87.9–95.0)

NBI, narrow-band imaging; UMEC, unified magnifying endoscopic classification; PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval.