Illustrative case 1. A and B, A 67-year-old patient who presented with a rapidly progressive coma associated with a right hemiplegia. Initial MR imaging demonstrates a basilar artery occlusion with a relatively small infarct core (posteriori circulation posterior circulation-ASPECTS = 8). The patient underwent intravenous thrombolysis combined with endovascular treatment. Considering the absence of recanalization of the basilar artery after 2 mechanical thrombectomy passes with a standard approach (C and D), intracranial angioplasty associated with cangrelor intravenous infusion was performed, allowing complete reperfusion (E). Day 1 MR imaging shows stability of the cerebellar infarction and patency of basilar artery without intracranial hemorrhage (F–H). The patient progressively recovered, and after 3 months, the mRS score was 0.