Table 4.
Detailed analyses of parameters of Lipinski's filter for the drug-likeness. The elaborated comparative analysis of all the seven drugs concerning parameters of Lipinski's filter.
| Compound | Molecular weight g/mole | H-Bond donors | H-bond acceptors | MLogP | Drug-likeliness |
|---|---|---|---|---|---|
| Ecamsule | 562.69 | 2 | 8 | 3.05 | Yes,1Violation |
| Naldemedine | 570.64 | 4 | 9 | 1.49 | Yes,1Violation |
| Ergotamine | 581.66 | 3 | 6 | 1.84 | Yes,1Violation |
| Ponatinib | 532.56 | 1 | 8 | 3.90 | Yes,1 Violation |
| Conivaptan | 498.57 | 2 | 3 | 4.07 | No Violation |
| Orap | 461.55 | 1 | 5 | 5.38 | Yes,1Violation (MLogP>4.15 |
| Trosec | 392.51 | 1 | 3 | -0.14 | No Violation |