Fig. 7.

Klotho gene ameliorate rhabdomyolysis (RM)-induced acute kidney injury (AKI) and prevents tubular injury (a) Creatinine and (b) blood urea nitrogen (BUN) levels at 2 day and 5 day for Rhabdomyolysis-induced AKI model mice treated with PBS, BMSCs-Klotho, BMSCs-EV and BMSCs (n = 6/each group). Date presented as mean ± standard deviation. ∗P < 0.05 versus PBS group, #P < 0.05 versus BMSCs-EV group and BMSCs group, ΔP < 0.05 versus CON group at the corresponding times. (c) The overexpression of Klotho prevents tubular injury and attenuates kidney peritubular capillary loss. Representative light microscopy images of hematoxylin and eosin-stained kidney sections on day 3 in the CON group, BMSCs-Klotho group, BMSCs-EV group and BMSCs group (∗: vascular blockage; ↓: Vascular necrosis; Magnification, ×200).