Table 3.
Multivariable Cox regression analysis of prognostic predictors for OS in patients with CRC
| Variable | N | NPLN | LNR | LODDS | ENE | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| Age(years) | ||||||||||
| <65 | 1 | 1 | 1 | 1 | 1 | |||||
| ≥65 | 1.801(1.186–2.734) | 0.006 | 1.817(1.197–2.760) | 0.005 | 1.742(1.150–2.641) | 0.009 | 1.758(1.159–2.666) | 0.008 | 1.687(1.114–2.555) | 0.014 |
| Nerve invasion | ||||||||||
| NO | 1 | 1 | 1 | 1 | 1 | |||||
| YES | 1.958(1.261–3.309) | 0.003 | 1.914(1.255–3.027) | 0.003 | 1.988(1.279–3.092) | 0.002 | 1.985(1.276–3.087) | 0.002 | 1.907(1.216–2.990) | 0.005 |
| Vessel invasion | ||||||||||
| NO | 1 | 1 | 1 | 1 | 1 | |||||
| YES | 1.120(0.716–1.751) | 0.62 | 1.118(0.714–1.749) | 0.627 | 1.503(0.665–1.668) | 0.824 | 1.057(0.667–1.676) | 0.814 | 1.087(0.683–1.730) | 0.752 |
| N stage | ||||||||||
| N1 | 1 | |||||||||
| N2 | 1.950(1.279–2.837) | 0.002 | ||||||||
| NPLN | ||||||||||
| NPLN1 | 1 | |||||||||
| NPLN2 | 1.934(1.297–2.883) | 0.001 | ||||||||
| LNR | ||||||||||
| LNR1 | 1 | |||||||||
| LNR2 | 1.714(1.123–2.615) | 0.013 | ||||||||
| LODDS | ||||||||||
| LODDS1 | 1 | |||||||||
| LODDS2 | 1.654(1.082–2.530) | 0.02 | ||||||||
| ENE | ||||||||||
| ENE1 | 1 | |||||||||
| ENE2 | 1.429(0.938–2.177) | 0.097 | ||||||||
Abbreviations: LNM, Lymph node metastasis; LNR, lymph node ratio; NPLN, number of positive lymph nodes; NDLN, number of dissected lymph nodes; LODDS, log ODDS; ENE, Extranodal extension.