Table 2.
Mean concentration of 5-FU and the metabolites dUr, FdUr, FdUMP, and dTMP in lymph node vs liver tissue before resection and pancreatic tumour vs pancreatic tissue after resection
| Before resection | 5-FU | FdUr | FdUMP | dUr | dTMP |
|---|---|---|---|---|---|
| Lymph node (pmol/g) | 701 ± 678 (n = 14) | 1.4 ± 1.5 (n = 14) | 18.5 ± 15.5 (n = 13) | 316 ± 273 (n = 14) | 169 ± 150 (n = 13) |
| Liver tissue (pmol/g) | 2229 ± 419 (n = 20) | 1.1 ± 1.9 (n = 20) | 6.1 ± 10.2 (n = 18) | 52.3 ± 41.3 (n = 20) | 81.8 ± 55.5 (n = 18) |
| P | 0.27 | 0.15 | 0.017 | 0.0002 | 0.48 |
| After resection | 5-FU | FdUr | FdUMP | dUr | dTMP |
| Pancreatic tumour (pmol/g) | 840 ± 2088 (n = 15) | 1.4 ± 2.1 (n = 14) | 6.7 ± 9.8 (n = 13) | 132 ± 166 (n = 15) | 105 ± 225 (n = 13) |
| Pancreatic tissue (pmol/g) | 639 ± 1212 (n = 15) | 0.79 ± 0.97 (n = 15) | 1.6 ± 2.2 (n = 15) | 210 ± 255 (n = 15) | 25.1 ± 33.9 (n = 15) |
| P | 0.84 | 0.67 | 0.068 | 0.30 | 0.11 |
| Before and after resection | 5-FU | FdUr | FdUMP | dUr | dTMP |
| Plasma before (pmol/ml) | 904 ± 1362 (n = 19) | 1.5 ± 5.2 (n = 19) | NA | 122 ± 164 (n = 19) | NA |
| Plasma after (pmol/ml) | 21 ± 60 (n = 18) | 0.20 ± 0.32 (n = 18) | NA | 269 ± 250 (n = 18) | NA |
| P | < 0.0001 | 0.71 | NA | 0.014 | NA |
Mean plasma concentration of 5-FU, dUr, and FdUr before vs after pancreatic resection
Lymph nodes and liver tissue from all patients were not sampled. Pancreatic tumour and pancreatic tissue was obtained if resection was performed. Plasma from 19 patients before and 18 patients after resection were sampled
5-FU, 5-flurorouracil; dUr, deoxyuridine; FdUr, 5-fluorodeoxyuridine; FdUMP, 5-fluorodeoxyuridine monophosphate; dTMP, deoxythymidine monophosphate; NA, not applicable; (n), patients