Table 1.

Systemic amyloidosis subtypes

Amyloid type	Acquired or hereditary	Precursor protein	Underlying disorder	Heart	Kidney liver	Liver	PN/AN	ST
AL	Acquired	Monoclonal immunoglobulin light chain	Plasma cell dyscrasia	+++	+++	++	+	++
hATTR	Hereditary	Abnormal TTR	Mutated TTR gene	+++	-	-	+++	-
wtATTR	Acquired	Normal TTR	-	+++	-	-	-	+
AA	Acquired	SAA	Inflammatory disorders	+ late	+++	+ late	+	-
ALECT2	Acquired	LECT2	Uncertain	-	+++	++	-	-
AGel	Hereditary	Abnormal gelsolin	Mutation in gelsolin gene	-	+	-	++ cranial	-
AB2M	Acquired or hereditary	AB2M	Long term dialysis	-	-	-	+	+
AApoA1	Hereditary	Abnormal ApoA1	Mutations in apolipoprotein A1 Gene	+	++	++	+	+ testis

AL, light chain amyloidosis; hATTR, hereditary transthyretin amyloidosis; wtATTR, wild-type transthyretin amyloidosis; AA, secondary amyloidosis; ALECT2: leukocyte chemotactic factor 2 amyloidosis; AB2M, beta-2-microglobulin amyloidosis; AApoA1, apolipoprotein A1 amyloidosis; PN, peripheral neuropathy; AN, autonomic neuropathy; ST, soft tissue; +++, very common; ++, common; +, less common; -, not reported