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. 2021 Aug 16;12:4951. doi: 10.1038/s41467-021-25251-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Violin plots in the top panel show the mean poly(A) tail length distribution across mRNAs from wild-type cells that were grown at different temperatures, binned by expression level in WT. The bottom panel shows the fraction of mRNAs DRS counts for each expression bin in a given condition. Box plots show median value (solid bold line) and 1st and 3rd quartiles, whiskers represent 1.5 × IQR (interquartile range). Outliers are marked as black points. b Same as (a) but for mRNAs that were at least fivefold upregulated (orange series) or downregulated (green series) following heat shock. Box plots show median value (solid bold line) and 1st and 3rd quartiles, whiskers represent 1.5 × IQR (interquartile range). Outliers are marked as black points. c Pie charts showing the nuclease sensitivity of heat-regulated mRNAs, which are listed in Supplementary Data 1. d Relationship between mRNA abundance and mean poly(A) tail length for cells that were grown in rich media (black, same as Fig. 1a) and MM-URA (blue) at 25 °C as explained in the main text.