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. 2021 Jun 21;125(4):534–546. doi: 10.1038/s41416-021-01450-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–c A time-course experiment following exposure of human umbilical vein endothelial cells (HUVECs) to 2, 5 or 10 Gy irradiation demonstrated reduced HUVEC cell number, morphological cell changes and increased number of cytoplasmic DNA fragments (DAPI, blue). d A ‘hanging drop’ assay demonstrated that endothelial cell sprouting was reduced with increasing irradiation dose at 48 h. Error bars = standard deviation. **P < 0.01, ***P < 0.0001; one-way ANOVA or unpaired Student’s t test comparing two data groups; data representative of n = 3 independent experiments.