Fig. 6. Neoadjuvant FRT improves the efficacy of subsequent VTP delivered 7 days later.

Analysis of post-VTP tumour growth delay of TRAMP-C1 flank allograft tumours treated with VTP 7 days post-FRT, compared to VTP alone. a, b Analysis of time for tumour regrowth from 150 mm³ at VTP delivery to the 400 mm³ end point revealed a trend towards enhanced tumour growth delay for VTP post-FRT compared to VTP alone for 9 mg/kg WST-11 and 7 mg/kg WST-11. c Combined analysis of mice treated with 7–9 mg/kg WST-11 VTP alone versus combined sequential FRT and 7–9 mg/kg WST-11 revealed a significantly enhanced tumour growth delay following administration of VTP if delivered 7 days post-FRT, compared with VTP alone. Data were analysed using a two-tailed unpaired t test for the bar chart and log-rank (Mantel–Cox) test for the Kaplan–Meier curves. *P < 0.05; **P < 0.01.