Fig. 9. Disease effects on local and global thresholding.

a A toy model of healthy brain connectivity with “known” connections including vulnerable edges which can be targeted by disease, and latent connections which are weaker than vulnerable connections. b When the model is targeted by disease, the vulnerable connections become weaker and do not survive a global threshold. c Although weakened by disease, the vulnerable connections still connect the nearest neighbour nodes within their communities, and these connections are restored or made visible by local thresholds.