Table 3.
Sex- and age- adjusted effects per GESLipid standard deviation and corresponding 95% confidence intervals (95% CI) on high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in linear regression models including main effects of a lipid-associated genetic effect allele sum score (GESLipid based on14), indicators of socioeconomic position (SEP; education groups and income tertiles) and interaction terms of GESLipid and indicators of SEP.
| HDL-C | LDL-C | TC | ||||
|---|---|---|---|---|---|---|
| β (95%-CI) | p | β (95%-CI) | p | β (95%-CI) | p | |
| Lipid ~ age + sex + GESLipid + Education + GESLipid*Education | ||||||
| n | 4502 | 4489 | 4503 | |||
| Intercept | −11.50 (−23.95; 1.00) | 0.070 | 49.89 (25.51; 74.26) | 6.1*10–05 | 80.32 (50.25; 110.40) | 1.7*10–07 |
| Age | 0.05 (−0.01; 0.11) | 0.106 | 0.25 (0.11; 0.38) | 4.1*10–04 | 0.33 (0.19; 0.478) | 8.1*10–06 |
| Sex | 14.79 (13.83; 15.75) | 3.9*10–183 | −1.07 (−3.28; 1.14) | 0.341 | 7.35 (5.00; 9.72) | 1.2*10–09 |
| GESLipid | 3.01 (2.24; 3.77) | 5.2*10–14 | 6.53 (4.68; 8.37) | 5.2*10–12 | 8.01 (6.08; 9.98) | 1.2*10–15 |
| Education (low) | 4.33 (−19.59; 28.26) | 0.723 | 52.31 (8.39; 96.24) | 0.020 | 56.57 (0.93; 112.21) | 0.046 |
| Education | −0.68 (−16.00; 14.64) | 0.931 | 1.84 (−26.52; 30.20) | 0.899 | 8.88 (−27.09; 44.86) | 0.628 |
| Education (high) | Ref | – | Ref | – | Ref | – |
| GESLipid × Edu# (low) | −0.56 (−2.09; 1.02) | 0.487 | −3.87 (−7.47; −0.32) | 0.033 | −3.64 (−7.44; 0.16) | 0.062 |
| GESLipid × Edu# | −0.05 (−1.07; 0.92) | 0.885 | 0.14 (−2.16; 2.43) | 0.911 | −0.52 (−2.96; 1.98) | 0.686 |
| GESLipid × Edu# (high) | Ref | – | Ref | – | Ref | – |
| Lipid ~ age + sex + GESLipid + Income + GESLipid*Income | ||||||
| n | 4232 | 4220 | 4233 | |||
| Intercept | −8.60 (−21.34; 4.14) | 0.186 | 55.82 (31.47; 80.16) | 7.2*10–06 | 88.25 (58.43; 118.07) | 7.0*10–09 |
| Age | 0.02 (−0.04; 0.08) | 0.483 | 0.27 (0.13; 0.40) | 1.8*10–04 | 0.35 (0.20; 0.50) | 3.2*10–06 |
| Sex | 14.07 (13.14; 15.01) | 5.5*10–173 | −0.14 (−2.41; 1.90) | 0.897 | 7.66 (5.37; 9.95) | 6.5*10–11 |
| GESLipid | 2.96 (2.14; 3.72) | 5.4*10–13 | 5.85 ( 4.01; 7.70) | 6.8*10–10 | 7.38 ( 5.46; 9.31) | 1.2*10–13 |
| Income (low) | 0.80 (−16.72; 18.33) | 0.928 | 6.54 (−24.83; 37.91) | 0.683 | −4.95 (−44.85; 34.94) | 0.808 |
| Income | 0.56 (−17.31; 18.42) | 0.951 | 0.40 (−32.81; 33.61) | 0.981 | 23.38 (−18.03; 64.79) | 0.269 |
| Income (high) | Ref | – | Ref | – | Ref | – |
| GESLipid × Inc$ (low) | −0.10 (−1.28; 1.02) | 0.833 | −0.23 (−2.79; 2.30) | 0.852 | 0.47 (−2.24; 3.22) | 0.726 |
| GESLipid × Inc$ | −0.15 (−1.28; 1.02) | 0.822 | 0.14 (−2.57; 2.84) | 0.911 | −1.56 (−4.42; 1.30) | 0.283 |
| GESLipid × Inc$ (high) | Ref | – | Ref | – | Ref | – |
#Education, $Income.